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Cognitive Deficits Associated with Sleep Apnea in Myotonic Dystrophy Type 1

Article type: Research Article

Authors: Gallais, Benjamin; | Gagnon, Cynthia; ; | Mathieu, Jean; ; | Richer, Louis | Jean, Stéphane | Laberge, Luc; ; ; ;

Affiliations: Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Jonquière, QC, Canada | École de Réadaptation, Faculté de Médecine et des sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada | Neuromuscular Clinic, Centre de Santé et de Services Sociaux de Jonquière, Jonquière, QC, Canada | Département des Sciences de la Santé, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada | ÉCOBES – Recherche et Transfert, Cégep de Jonquière, Jonquière, QC, Canada

Note: [] Correspondence to: B. Gallais, Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), 2230 rue de l'Hôpital, G7X 7X2 Jonquière, QC, Canada. E-mail: [email protected]

Keywords: Myotonic dystrophy type 1, neuromuscular disorders, sleep-disordered breathing, BMI, neuropsychological tests, cognitive function

DOI: 10.3233/JND-140012

Journal: Journal of Neuromuscular Diseases, vol. 1, no. 1, pp. 95-98, 2014

Published: 2014
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Abstract

Although sleep-disordered breathing and cognitive impairment are common features of patients with myotonic dystrophy type 1 (DM1), little is known about their relationship. Forty-three adult DM1 patients underwent 2 sequential polysomnographic sessions and a neuropsychological test battery (intellectual functioning, attention, language, memory, and executive functions). Lower scores in attention, vigilance, and executive functioning tests were associated with higher number of apneic/hypopneic episodes per hour of sleep and longer total sleep time at an oxyhemoglobin saturation of less than 90%. Results suggest a potential role for nighttime breathing problems in the cognitive impairment often observed in DM1 patients.

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