Comparison of maternal 25 (OH) vitamin D levels between premature infants with/without asphyxia

Article type: Research Article

Authors: Zakerihamidi, M.^{a; 1} | Rakhshanizadeh, F.^{b; 2} | Moradi, A.^{c; d; 3} | Boskabadi, H.^{b; *}

Affiliations: [a] Department of Midwifery, School of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran | [b] Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | [c] Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran | [d] Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence: [*] Address for correspondence: Hassan Boskabadi MD, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Tel: +98-511-8412069. E-mail: [email protected]; ORCID ID: 0000-0003-4022-5426.

Note: [1] ORCID ID: 0000-0002-6543-9095.

Note: [2] ORCID ID: 0000-0002-9000-8051.

Note: [3] ORCID ID: 0000-0003-3866-0867.

Abstract: OBJECTIVES:Perinatal asphyxia is the main risk factor for mortality and morbidity in neonates and neurological disorders in survived infants. We compared the neonatal and maternal 25 (OH) vitamin D levels in neonates with/without asphyxia. MATERIALS AND METHODS:This cross-sectional research was done on 229 neonates (including 158 neonates [69%] without asphyxia [control group] and 71 neonates [31%] with asphyxia [case group]) from 2020 to 2023 using the available sampling method. 25 (OH) Vit D levels in mothers and neonates were assessed and compared in the 2 groups. The data collection instrument was a researcher-made checklist, containing the maternal and neonatal characteristics and laboratory evaluations. Data were analyzed by SPSS 23 using the t-test. RESULTS:The mean maternal 25 (OH) Vit D levels in the case and control groups were 16.34±11.87 and 22.80±12.67 ng/mL, respectively. The mean neonatal 25 (OH) Vit D levels in the case and control groups were respectively 12.13±8.62 and 19.55±11.62 ng/mL (P = 0.002). The case group showed severer maternal and neonatal 25 (OH) Vit D deficiency (P = 0.000) compared to the control group. CONCLUSIONS:Neonatal and maternal 25 (OH) Vit D deficiency can increase the risk of perinatal asphyxia. Therefore, administration of 25 (OH) Vit D supplements to pregnant mothers may reduce the incidence of asphyxia.

Keywords: Asphyxia, mothers, newborn, prematurity, 25 (OH) Vitamin D

DOI: 10.3233/NPM-230229

Journal: Journal of Neonatal-Perinatal Medicine, vol. 17, no. 4, pp. 583-588, 2024