Neonatal complex arrhythmias possibly related to a TTN mutation

Article type: Case Report

Authors: Evans, William N.^{a; b; *} | Acherman, Ruben J.^{a; b} | Law, Ian H.^{a; c} | Von Bergen, Nicholas H.^{a; d} | Samson, Ricardo A.^{a; b} | Restrepo, Humberto^{a; b}

Affiliations: [a] Children’s Heart Center Nevada, Las Vegas, NV, USA | [b] Department of Pediatrics, Division of Cardiology, University of Nevada, Reno School of Medicine, Las Vegas, NV, USA | [c] Department of Pediatrics, Division of Cardiology, University of Iowa Carver College of Medicine, Iowa City, USA | [d] Department of Pediatrics, Division of Cardiology, University of Wisconsin-Madison, Madison, WI, USA

Correspondence: [*] Address for correspondence: William N. Evans, MD., Children’s Heart Center Nevada, 3006 S. Maryland Pkwy, Ste. 690, Las Vegas, NV 89109, USA. Tel.: +1 702 732 1290; Fax: +1 702 732 1385; E-mail: wnevans50@aol.

Abstract: We describe a neonate born with complex arrhythmias that included concurrent atrial and ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN gene, which codes for titin, a large protein found in striated muscle sarcomeres. The complex arrhythmias were successfully treated with amiodarone and flecainide. The patient remains asymptomatic with normal biventricular function. We speculate that the complex arrhythmias and TTN gene mutation may be related.

Keywords: Complex arrhythmia, neonate, TTN gene mutation

DOI: 10.3233/NPM-16120

Journal: Journal of Neonatal-Perinatal Medicine, vol. 10, no. 3, pp. 343-346, 2017