PPHN treated with sildenafil and inhaled nitric oxide delivered via nasal continuous positive airway pressure

Article type: Research Article

Authors: Al-Alaiyan, Saleh | Smith, Dean | Dawoud, Magdy | Al-Hazzani, Fahad

Affiliations: Division of Neonatology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Note: [] Corresponding author: Saleh Al-Alaiyan, M.D., Department of Pediatrics (MBC-58), King Faisal Specialist Hospital and Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia. Tel.: +966 1 442 7761; Fax: +966 1 442 7784; E-mail: [email protected]

Abstract: We report the case of a newborn infant who developed persistent pulmonary hypertension of the newborn and was successfully treated with a combination of inhaled nitric oxide (iNO), nasal continous positive airway pressure (nCPAP) and seldinafil. This approach may decrease the need for intubation and mechanical ventilation and subsequently lung injury in similar cases.

Keywords: Pulmonary hypertension, nitric oxide, sildenafil, nasal CPAP

DOI: 10.3233/NPM-2010-0135

Journal: Journal of Neonatal-Perinatal Medicine, vol. 3, no. 4, pp. 343-345, 2010