Affiliations: [a] Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran | [b] Department of Physiology, Payam Noor University of Iran, Tehran, Iran | [c] Matrix Dynamics Group, University of Toronto, Toronto, Canada
Correspondence:
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Corresponding author: Leila Sadeghi, Subdivision of Biochemistry, Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran, P.O. Box 5166616471, Tabriz, Iran. Tel.: (+9841) 35442617; E-mails: [email protected], [email protected].
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder greatly accompanied by oxidative stress and acetylcholine reduction in synaptic cleft that leads to dementia. Previously approved there is correlation between nucleus basalis of Meynert (NBM) degeneration and loss of memory, learning ability and thought. The aim of this study was to investigate improving effects of Echium amoenum aqueous extract on memory deficient, pathophysiological and oxidative damages imposed by NBM lesion in rats as documented AD model. Results showed NBM destruction causes hash oxidative stress that possibly leads to neurodegeneration in hippocampus tissue. Orally administration of plant extract significantly reduced oxidative stress by reactive molecules scavenging that resulted to decrease lipid peroxidation also. Plant extract treatment inhibited acetylcholine esterase enzyme (more than 5 folds) in hippocampus tissue related to NBM lesioned rats. Histological studies approved NBM lesion causes harsh neurodegeneration in hippocampus tissue possibly by acetylcholine reduction that was compensated by plant extract protective effects. Interestingly improving effects of plant in molecular level causes improved spatial learning ability in Morris water maze test. By considering pathophysiological and molecular similarities between AD and NBM lesion model, E. amoenum could be used as a therapeutic adjuvant in patients suffering from Alzheimer or similar cognitive disorders.
