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Article type: Research Article
Authors: Qi, Zexiua; 1 | Yang, Beia; 1 | Giampieri, Francescaa; b | Cianciosi, Danilaa | Alvarez-Suarez, José Miguelc; d | Elexpuru-Zabaleta, Mariab | Quiles, Josè L.e | Forbes-Hernandez, Tamara Y.e | Zhang, Dif | Bai, Weibing | Tian, Lingming | Mezzetti, Brunoh | Battino, Maurizioa; b; i | Armas Diaz, Yasmanya; *
Affiliations: [a] Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy | [b] Research Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres, 21, Santander, Spain | [c] Laboratorio de Bioexploración. Universidad San Francisco de Quito USFQ, Quito, Ecuador | [d] Laboratorio de Investigación en Ingeniería en Alimentos (LabInAli), Departamento de Ingeniería en Alimentos, Colegio de Ciencias e Ingenierías, Universidad San Francisco de Quito USFQ, Quito, Ecuador | [e] Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Avda del Conocimiento s/n, Parque Tecnologico de la Salud, Armilla, Granada, Spain | [f] School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China | [g] Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety | [h] Department of Agricultural, Food and Environmental Sciences, Università Politecnica Delle Marche, Via Brecce Bianche 10, Ancona, Italy | [i] International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang, China
Correspondence: [*] Correspondence to:Yasmany Armas Diaz, Department of Clinical Sciences, Polytechnic University of Marche, Ancona, 60131, Ancona. Tel.: +390712204163; E-mail: [email protected].
Note: [1] These authors have equally contributed.
Abstract: Red raspberries are gaining attention more and more for their nutritional and bioactive components, with potential health effects such as antitumor properties. This review aims to describe the antioxidant activities of red raspberries, emphasizing the role of anthocyanins and ellagitannins as primary contributors among red raspberry polyphenols; it also outlined the connection between red raspberries and their role in inhibiting cancer cell growth by regulating oxidative stress. Numerous studies suggest that red raspberries are able to block cancer cell progression by inhibiting proliferation, migration, and autophagy, as well as regulating the cell cycle, angiogenesis, and DNA damage repair. This review sheds light to the growing evidence supporting antioxidants as a crucial link between fruit consumption and cancer prevention.
Keywords: Red raspberry, anthocyanins, ellagitannins, oxidative stress, cancer
DOI: 10.3233/JBR-240004
Journal: Journal of Berry Research, vol. 14, no. 1, pp. 61-71, 2024
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