Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Platonova, Elena Y.a | Zemskaya, Nadezhda V.a | Shaposhnikov, Mikhail V.a | Golubev, Denis A.a | Kukuman, Daria V.a | Pakshina, Natalya R.a | Ulyasheva, Natalia S.a | Punegov, Vasily V.a | Patov, Sergey A.b | Moskalev, Alexeya; *
Affiliations: [a] Institute of Biology of Komi Scientific Centre of the Ural Branch of the RAS, Syktyvkar, Russian Federation | [b] Institute of Chemistry of Komi Scientific Centre of the Ural Branch of the RAS, Syktyvkar, Russian Federation
Correspondence: [*] Corresponding author: A.A. Moskalev, Institute of Biology of Komi Scientific Centre of the Ural Branch of the RAS, 167982, Syktyvkar, Russian Federation; Tel.: +7 8212 312 894; Fax: +7 8212 240 163; E-mail: [email protected].
Abstract: BACKGROUND:×Sorbaronia mitschurinii (also known as Aronia mitschurinii) is an intergeneric hybrid of×Sorbaronia fallax and Aronia melanocarpa. ×S. mitschurinii berry is a rich source of phytochemicals such as flavonoids and anthocyanins, which have a broad range of health benefits and a great geroprotective potential. OBJECTIVES:The goal of the present study was to investigate the geroprotective effects of Sorbaronia berry ethanolic extract (SBE) in Drosophila melanogaster and whether these effects depend on the concentration of SBE, duration of treatment, age, and sex. METHODS:SBE was used to supplement a diet of Drosophila imagoes throughout life, during 2 weeks after the imago hatching, and from 4 to 6 weeks of age. The relationship between the SBE effects on lifespan, stress resistance and the expression of stress response genes were examined. RESULTS:SBE treatment at 1-2 and 4-6 weeks of life increased the lifespan, while treatment throughout life reduced lifespan. SBE treatment increased Drosophila resistance to oxidative stress and starvation, but not to hyperthermia. A statistically significant effect of SBE treatment on the expression level of per, keap1, hif1, hsp27, hsp68, hsp83, and sirt1 genes in flies of both sexes and on sod1 expression only in female flies was demonstrated. CONCLUSIONS:The observed relationship between SBE concentration and lifespan effects suggests that the life-extending effect of SBE may be associated with the mechanism of hormesis.
Keywords: Sorbaronia berry extract, lifespan, Drosophila melanogaster, geroprotector, aging
DOI: 10.3233/JBR-211502
Journal: Journal of Berry Research, vol. 12, no. 1, pp. 73-92, 2022
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]