Affiliations: [a] School of Public Health, Dalian Medical University, Dalian, China
| [b] National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, China
| [c] Liaoning Provincial Key Laboratories for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital of Dalian Medical University, Dalian, China
| [d] Institute of Neurology, Sichuan Academy of Medical Sciences-Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
Correspondence:
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Correspondence to: Qingshan Wang, PhD, Professor, School of Public Health, Dalian Medical University, Dalian, 116044, China; National-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, China. E-mail: [email protected].
Abstract: Alzheimer’s disease (AD) is a complex, heterogeneous, and progressive neurodegenerative dementia. Although the majority of AD research has primarily focused on disease-associated alterations of the cortex and hippocampus in the cerebrum, emerging evidence has highlighted the cerebellum’s involvement in sleep, cognition, and AD. In this commentary, we discuss a recently published article in Alzheimer’s and Dementia, which examines changes in cerebellar electrophysiology, sleep-wake cycles, and neuropathology in APPswe/PS1ΔE9 mice. We also explore the potential role of the cerebellum in AD, offering a fresh perspective on the study of cerebellar involvement in the disease.
