Contributions of Cardiovascular Burden, Peripheral Inflammation, and Brain Integrity on Digital Clock Drawing Performance in Non-Demented Older Adults

Article type: Research Article

Authors: Dion, Catherine^a | Tanner, Jared J.^a | Libon, David J.^{b; c} | Price, Catherine C.^{a; d; *}

Affiliations: [a] Clinical and Health Psychology, University of Florida, Gainesville, FL, USA | [b] Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University, Glassboro, NJ, USA | [c] Department of Psychology, Rowan University, Glassboro, NJ, USA | [d] Department of Anesthesiology, University of Florida, Gainesville, FL, USA

Correspondence: [*] Correspondence to: Catherine Price, PhD, Associate Professor, Clinical and Health Psychology, University of Florida, Gainesville, FL, 32610, USA. Tel.: +1 352 273 5929; E-mail: [email protected].

Abstract: Background:Greater cardiovascular burden and peripheral inflammation are associated with dysexecutive neuropsychological profiles and a higher likelihood of conversion to vascular dementia. The digital clock drawing test (dCDT) is useful in identifying neuropsychological dysfunction related to vascular etiology. However, the specific cognitive implications of the combination of cardiovascular risk, peripheral inflammation, and brain integrity remain unknown. Objective:We aimed to examine the role of cardiovascular burden, inflammation, and MRI-defined brain integrity on dCDT latency and graphomotor metrics in older adults. Methods:184 non-demented older adults (age 69±6, 16±3 education years, 46% female, 94% white) completed dCDT, vascular assessment, blood draw, and brain MRI. dCDT variables of interest: total completion time (TCT), pre-first hand latency, digit misplacement, hour hand distance from center, and clock face area. Cardiovascular burden was calculated using the Framingham Stroke Risk Profile (FSRP-10). Peripheral inflammation markers included interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-alpha, and high sensitivity C-reactive protein. Brain integrity included bilateral entorhinal cortex volume, lateral ventricular volume, and whole brain leukoaraiosis. Results:FSRP-10, peripheral inflammation, and brain integrity explained an additional 14.6% of the variance in command TCT, where FSRP-10 was the main predictor. FSRP-10, inflammatory markers, and brain integrity explained an additional 17.0% in command digit misplacement variance, with findings largely driven by FSRP-10. Conclusion:Subtle graphomotor behavior operationalized using dCDT metrics (i.e., TCT and digit misplacement) is partly explained by cardiovascular burden, peripheral inflammation, and brain integrity and may indicate vulnerability to a disease process.

Keywords: Alzheimer’s disease, cardiovascular diseases, cognition, heart disease risk factors, inflammation

DOI: 10.3233/JAD-221011

Journal: Journal of Alzheimer's Disease, vol. 95, no. 2, pp. 453-467, 2023