Motoric Cognitive Risk Syndrome Among Chinese Older Adults with White Matter Lesions: A Cross-Sectional Observational Study

Article type: Short Communication

Authors: Zhào, Hóngyi^{a; b; 1} | Wei, Wei^{a; 1} | Xie, Hongyang^a | Huang, Yonghua^{a; *}

Affiliations: [a] Department of Neurology, Seventh Medical Centre of PLA General Hospital, Beijing, China | [b] Department of Neurology, Number 984 Hospital of the PLA, Beijing, China

Correspondence: [*] Correspondence to: Yonghua Huang, Department of Neurology, Seventh Medical Centre of PLA General Hospital, Beijing, China. E-mail: [email protected].

Note: [1] These authors contributed equally to this work.

Abstract: Brain aging is characterized by the declines in motor and cognitive features. The present study is to detect motor cognitive risk syndrome (MCRS) in older adults with white matter lesions (WML). 134 WML aged patients were recruited and diagnosed with the criteria for MCRS. Numerous cognitive function tests and walking tests were performed. The frequency of MCRS is 28.35%. Verbal fluency test, Mini-Mental State Examination, and dual-task walking speed were independent risk factor of MCRS. These findings indicated that MCRS was common in WML seniors. MCRS was associated with the pathologies of WML in older adults.

Keywords: Aging, cerebral small vessel disease, dual-task walking, magnetic resonance imaging, motoric cognitive risk syndrome, white matter lesions

DOI: 10.3233/JAD-220712

Journal: Journal of Alzheimer's Disease, vol. 91, no. 3, pp. 925-931, 2023