Physical Activity Self-Report Is Not Reliable Among Subjects with Mild Vascular Cognitive Impairment: The AFIVASC Study

Article type: Research Article

Authors: Verdelho, Ana^{a; b; c; *} | Correia, Manuel^d | Ferro, José Manuel^{a; b} | Madureira, Sofia^b | Vilela, Pedro^e | Rodrigues, Mário^b | Borges, Mariana^b | Oliveira, Vanessa^d | Santos, Ana Catarina^b | Gonçalves-Pereira, Manuel^f | Santa-Clara, Helena^g

Affiliations: [a] Department of Neurosciences and Mental Health, CHLN-Hospital de Santa Maria, Lisbon, Portugal | [b] Instituto de Medicina Molecular João Lobo Antunes – IMM, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal | [c] Instituto de Saúde Ambiental – ISAMB, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal | [d] Neurology Service, Hospital de Santo António, Centro Hospitalar do Porto and Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, Portugal | [e] Neuroradiology Department, Hospital da Luz, Lisboa, Portugal | [f] Comprehensive Health Research Centre (CHRC), CEDOC, NOVA Medical School/Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal | [g] Exercise and Health Laboratory, Faculdade de Motricidade Humana, Centro Interdisciplinar de Estudo da Performance Humana –CIPER, Universidade de Lisboa, Lisboa, Portugal

Correspondence: [*] Correspondence to: Ana Verdelho, Department of Neurosciences, Hospital de Santa Maria, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-035 Lisbon, Portugal. Tel./Fax: +00351 21 7957474; E-mail: [email protected].

Abstract: Background:The World Health Organization (WHO) recommends a minimum of 150 minutes of moderate physical activity per week. Adherence to these recommendations is difficult to assess. Objective:We aimed to evaluate the validity of self-reported physical activity in mild vascular cognitive impairment (mVCI) and whether physical activity was associated with cognitive status, by using baseline data from a randomized controlled trial. Methods:A hundred and four subjects with mVCI were included (mean age 72 years; 51% women). Subjects underwent neurological, physical, and comprehensive neuropsychological assessments. Adherence to WHO physical activity recommendations was evaluated using both self-reported information and objective measures (accelerometry). Results:There was poor agreement (kappa = 0.106) between self-report of following WHO recommendations and actually fulfilling them according to accelerometry. Only 16.6% of participants reported following WHO recommendations and displayed compatible values according to the accelerometer. Participants whose accelerometry values confirmed adherence to WHO recommendations had better performance in a global measure of cognition, attention, and mental speed processing. In multiple regression analyses, education and accelerometry values in accordance with WHO recommendations were independently associated with the global measure of cognition, attention, and processing speed, controlling for sex, age, and depressive symptoms. Accelerometry results were not associated with memory and executive functions. Conclusion:In this sample of mVCI subjects, self-reported physical activity displayed poor agreement with accelerometry values, suggesting that objective measures of physical activity are preferable. Physical activity (performed, at least, according to WHO recommendations) was associated with better cognitive performance overall.

Keywords: Accelerometry, cognition, dementia, prevention

DOI: 10.3233/JAD-215381

Journal: Journal of Alzheimer's Disease, vol. 87, no. 1, pp. 405-414, 2022