Affiliations: [a] Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
| [b] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
| [c] Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
| [d] Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA
| [e] Department of Radiology, Washington University, St Louis, MO, USA
| [f] Stroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, USA
Correspondence:
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Correspondence to: Michelle C. Johansen, MD, PhD, 600 N. Wolfe Street, Phipps 4 Suite 446, Baltimore, MD 21287, USA. Tel.: +1 410 614 2381; Fax: +1 410 614 9807; E-mail: [email protected].
Abstract: The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.
