Affiliations: [a] Universidad Francisco de Vitoria, Madrid, Spain | [b] Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico | [c] Unidad de Investigación Epidemiológica y de Servicios de Salud, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico | [d] Centro Universitario Hygiea, Madrid, Spain
Correspondence:
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Correspondence to: Miguel Angel Cuevas-Budhart, Nursing Program Coordinator, Unidad de Investigación Médica en Enfermedades Nefrológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Tel.: +52 5513914955; E-mails: [email protected] and [email protected].
Abstract: Background:In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated. Objective:To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer’s disease. Method:Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish. Results:Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. Conclusion:The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.
Keywords: Alzheimer’s disease, gut-brain axis, gut microbiome, microbiota, Parkinson’s disease
