Association Between Serum Vitamins and the Risk of Alzheimer’s Disease in Chinese Population

Article type: Research Article

Authors: Liu, Xi-Xi^a | Wu, Peng-Fei^b | Liu, Ying-Zi^a | Jiang, Ya-Ling^a | Wan, Mei-Dan^a | Xiao, Xue-Wen^a | Yang, Qi-Jie^a | Jiao, Bin^{a; c; d; e; f} | Liao, Xin-Xin^g | Wang, Jun-Ling^{a; c; d; e; f} | Liu, Shao-Hui^h | Zhang, Xuewei^{h; *} | Shen, Lu^{a; c; d; e; f; i; *}

Affiliations: [a] Department of Neurology, Xiangya Hospital, Central South University, Changsha, China | [b] Hunan Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, China | [c] National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China | [d] Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, China | [e] Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China | [f] Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China | [g] Department of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha, China | [h] Health Management Center, Xiangya Hospital, Central South University, Changsha, China | [i] Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China

Correspondence: [*] Correspondence to: Lu Shen, MD, PhD, Department of Neurology, Xiangya Hospital, Central South University, Changsha, China. Tel.: +86 731 89753041; Fax: +86 731 84327332; E-mails: [email protected] and [email protected]; Xuewei Zhang, MD, Health Management Center, Xiangya Hospital, Central South University, Changsha, China. E-mail: [email protected].

Abstract: Background:Alzheimer’s disease (AD) is a chronic and fatal neurodegenerative disease; accumulating evidence suggests that vitamin deficiency is associated with the risk of AD. However, studies attempting to elucidate the relationship between vitamins and AD varied widely. Objective:This study aimed to investigate the relationship between serum vitamin levels and AD in a cohort of the Chinese population. Methods:A total of 368 AD patients and 574 healthy controls were recruited in this study; serum vitamin A, B1, B6, B9, B12, C, D, and E were measured in all participants. Results:Compared with the controls, vitamin B2, B9, B12, D, and E were significantly reduced in AD patients. Lower levels of vitamin B2, B9, B12, D, and E were associated with the risk of AD. After adjusting for age and gender, low levels of vitamin B2, B9, and B12 were still related to the risk of AD. In addition, a negative correlation was determined between vitamin E concentration and Activity of Daily Living Scale score while no significant association was found between serum vitamins and age at onset, disease duration, Mini-Mental State Examination, and Neuropsychiatric Inventory Questionnaire score. Conclusion:We conclude that lower vitamin B2, B9, B12, D, and E might be associated with the risk of AD, especially vitamin B2, B9, and B12. And lower vitamin E might be related to severe ability impairment of daily activities.

Keywords: Alzheimer’s disease, homocysteine, nutrient, vitamin

DOI: 10.3233/JAD-215104

Journal: Journal of Alzheimer's Disease, vol. 85, no. 2, pp. 829-836, 2022