A 9-Year Comparison of Dementia Prevalence in Korea: Results of NaSDEK 2008 and 2017

Article type: Research Article

Authors: Suh, Seung Wan^a | Kim, You Joung^b | Kwak, Kyung Phil^c | Kim, Kiwon^d | Kim, Moon-Doo^e | Kim, Byung-Soo^f | Kim, Bong Jo^g | Kim, Shin Gyeom^h | Kim, Jeong Lanⁱ | Kim, Tae Hui^j | Moon, Seok Woo^k | Park, Kyung Won^l | Park, Jong-Il^{m; n} | Park, Joon Hyuk^o | Bae, Jae Nam^p | Seo, Jiyeong^q | Seong, Su Jeong^a | Son, Sang Joon^r | Shin, Il-Seon^{s; t} | Ryu, Seung-Ho^u | Lee, Kang Joon^v | Lee, Nam-Jin^w | Lee, Dong Young^{x; y} | Lee, Dong Woo^z | Lee, Seok Bum^aa | Lee, Chang Uk^{bb; cc} | Chang, Sung Man^f | Jeong, Hyun-Ghang^{dd; ee} | Cho, Maeng Je^y | Cho, Seong-Jin^ff | Jhoo, Jin Hyeong^gg | Choe, Young Min^hh | Han, Ji Wonⁱⁱ | Kim, Ki Woong^{y; ii; jj; *}

Affiliations: [a] Department of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea | [b] National Institute of Dementia, Seongnam, Korea | [c] Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, Korea | [d] Department of Psychiatry, Veteran Health Service Medical Center, Seoul, Korea | [e] Department of Psychiatry, College of Medicine, Jeju National University, Jeju, Korea | [f] Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea | [g] Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju, Korea | [h] Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Korea | [i] Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea | [j] Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, Korea | [k] Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju, Korea | [l] Department of Neurology, Dong-A University College of Medicine and Department of Translational Biomedical Sciences, Graduate School of Dong-A University, Busan, Korea | [m] Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Korea | [n] Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea | [o] Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea | [p] Department of Psychiatry, Inha University Hospital, Incheon, Korea | [q] Department of Psychiatry, Gyeongsang National University Changwon Hospital, Changwon, Korea | [r] Department of Psychiatry, Ajou University School of Medicine, Suwon, Korea | [s] Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea | [t] Department of Psychiatry, Chonnam National University Hwasun Hospital, Hwasun, Korea | [u] Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Korea | [v] Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea | [w] Department of Psychiatry, Jeonju City Welfare Hospital for the Elderly, Jeonju, Korea | [x] Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea | [y] Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea | [z] Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Korea | [aa] Department of Psychiatry, Dankook University Hospital, Cheonan, Korea | [bb] Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea | [cc] Catholic Agro-Medical Center, The Catholic University of Korea, Seoul, Korea | [dd] Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea | [ee] Korea University Research Institute of Mental Health, Seoul, Korea | [ff] Department of Psychiatry, Gachon University, School of Medicine, Incheon, Korea | [gg] Department of Psychiatry, Kangwon National University, School of Medicine, Chuncheon, Korea | [hh] Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea | [ii] Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea | [jj] Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul, Korea

Correspondence: [*] Correspondence to: Ki Woong Kim, MD, PhD, Department of Neuropsychiatry, Seoul National University, College of Medi-cine, and Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea. Tel.: +82 31 787 7432; Fax: +82 31 787 4058; E-mail: [email protected].

Abstract: Background:In many high-income Western countries, the prevalence of dementia had been reduced over the past decades. Objective:We investigated whether the prevalence of all-cause dementia, Alzheimer’s disease, vascular dementia, and mild cognitive impairment (MCI) had changed in Korea from 2008 to 2017. Methods:Nationwide Survey on Dementia Epidemiology of Korea (NaSDEK) in 2008 and 2017 was conducted on representative elderly populations that were randomly sampled across South Korea. Both surveys employed a two-stage design (screening and diagnostic phases) and diagnosed dementia and MCI according to the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders and the consensus criteria from the International Working Group, respectively. The numbers of participants aged 65 years or older in the screening and diagnostic phases were 6,141 and 1,673 in the NaSDEK 2008 and 2,972 and 474 in the NaSDEK 2017, respectively. Results:The age- and sex-standardized prevalence of all-cause dementia and Alzheimer’s disease showed nonsignificant decrease (12.3% to 9.8%, odds ratio [OR] = 0.89, 95% confidence interval [CI] = 0.54–1.48 for all-cause dementia; 7.6% to 6.8%, OR [95% CI] = 0.91 [0.58–1.42] for Alzheimer’s disease). Vascular dementia decreased in the young-old population aged less than 75 years (2.7% to 0.001%, OR [95% CI] = 0.04 [0.01–0.15]) and in women (1.9% to 0.5%, OR [95% CI] = 0.27 [0.10–0.72]) while MCI remained stable (25.3% to 26.2%, OR [95% CI] = 1.08 [0.67–1.73]). Conclusion:We found that the prevalence of dementia in Korea showed a nonsignificant decrease between 2008 and 2017.

Keywords: Alzheimer’s disease, dementia, mild cognitive impairment, prevalence, vascular dementia

DOI: 10.3233/JAD-201588

Journal: Journal of Alzheimer's Disease, vol. 81, no. 2, pp. 821-831, 2021