Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Review Article
Authors: Huang, Zhentinga; b; 1 | Yan, Qiana; b; d; 1 | Wang, Yangyanga; b | Zou, Qiana; b | Li, Jinga; b | Liu, Zhouc; * | Cai, Zhiyoua; b; *
Affiliations: [a] Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, Chongqing, China | [b] Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, Chongqing, China | [c] Department of Neurology, Affiliated Hospital of Guangdong Medical University, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Zhanjiang, Guangdong, China | [d] Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, China
Correspondence: [*] Correspondence to: Zhiyou Cai, Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 312 Zhongshan First Road, Yuzhong District, Chongqing 400013, People’s Republic of China. Tel./Fax: +86 23 63515796; E-mail: [email protected].; Zhou Liu, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, No. 57 South Renmin Avenue, Xiashan, 524023 Zhanjiang, Guangdong, China. E-mail: [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: Mitochondrial dysfunction has been widely reported in several neurodegenerative disorders, including in the brains of patients with Alzheimer’s disease (AD), Parkinson’s disease, and Huntington disease. An increasing number of studies have implicated altered glucose and energy metabolism in patients with AD. There is compelling evidence of abnormalities in some of the key mitochondrial enzymes involved in glucose metabolism, including the pyruvate dehydrogenase and α-ketoglutarate dehydrogenase complexes, which play a great significance role in the pathogenesis of AD. Changes in some of the enzyme activities of the mitochondria found in AD have been linked with the pathology of amyloid-β (Aβ). This review highlights the role of mitochondrial function in the production and clearance of Aβ and how the pathology of Aβ leads to a decrease in energy metabolism by affecting mitochondrial function.
Keywords: Alzheimer’s disease, amyloid-β , dysfunction, mitochondria, pathology
DOI: 10.3233/JAD-200519
Journal: Journal of Alzheimer's Disease, vol. 78, no. 2, pp. 505-514, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]