Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Sugimoto, Taikia; b; c | Ono, Reic | Kimura, Aia; b; d | Saji, Naokia | Niida, Shumpeib | Sakai, Toshihiroe | Rakugi, Hiromif | Toba, Kenjia | Sakurai, Takashia; d; *
Affiliations: [a] Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, Obu, Japan | [b] Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Japan | [c] Department of Public Health, Kobe University Graduate School of Health Sciences, Kobe, Japan | [d] Department of Cognition and Behavior Science, Nagoya University Graduate School of Medicine, Nagoya, Japan | [e] Shinmachi Sakai Clinic, Minoh, Japan | [f] Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan
Correspondence: [*] Correspondence to: Takashi Sakurai, MD, PhD, Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, 474-8511, Japan. Tel.: +81 562 46 2311; Fax: +81 562 46 8394; E-mail: [email protected].
Abstract: Background:Very few studies have investigated the impact of cognitive frailty in clinical settings, especially in memory clinic populations. Objective:To examine the impact of cognitive frailty on activities of daily living (ADL), cognitive function, and conversion to dementia among memory clinic patients with mild cognitive impairment (MCI). Methods:The subjects of this retrospective study were 248 MCI patients (mean age, 76.3±5.4 years; females, 60.9%). All subjects completed a comprehensive geriatric assessment at baseline and at least one assessment during 3-year follow-up. Frailty was defined by generating a frailty index (FI), and MCI patients with frailty (FI≥0.25) were considered to represent cognitive frailty. As primary outcomes, the Barthel Index, Mini-Mental State Examination, and incident dementia were evaluated during follow-up. At baseline, patients were assessed for apolipoprotein E (APOE) phenotype. A linear mixed model, as well as a Cox proportional hazards regression model with adjustment for confounding variables, was performed. Results:Of these patients, 75 (30.2%) were classified as cognitive frail. APOE ɛ4 carriers accounted for 26.7% of those with cognitive frailty and 44.5% of those without (p = 0.008). Cognitive frail patients showed a faster ADL decline (estimate, –1.04; standard error, 0.38; p = 0.007) than patients without cognitive frailty. Cognitive frailty was not associated with cognitive decline and incident dementia. Conclusion:Our findings demonstrated cognitive frailty increases the risk of dependence but not cognitive outcomes. Cognitive frailty may have heterogeneous conditions, including APOE ɛ4-related pathologies, which may affect the cognitive trajectories of patients with MCI.
Keywords: Cognitive frailty, disability, frailty, memory clinic, mild cognitive impairment, older persons
DOI: 10.3233/JAD-191135
Journal: Journal of Alzheimer's Disease, vol. 76, no. 3, pp. 895-903, 2020
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]