National Dementia BioBank: A Strategy for the Diagnosis and Study of Neurodegenerative Diseases in México

Article type: Research Article

Authors: Reyes-Pablo, Aldelmo Emmanuel^{a; b} | Campa-Córdoba, B. Berenice^{a; b} | Luna-Viramontes, Nabil Itzi^{a; b} | Ontiveros-Torres, Miguel Ángel^c | Villanueva-Fierro, Ignacio^d | Bravo-Muñoz, Marely^a | Sáenz-Ibarra, Bárbara^e | Barbosa, Oralia^f | Guadarrama-Ortíz, Parménides^g | Garcés-Ramírez, Linda^b | de la Cruz, Fidel^b | Harrington, Charles R.^h | Martínez-Robles, Sandra^a | González-Ballesteros, Erik^a | Perry, Georgeⁱ | Pacheco-Herrero, Mar^{j; *} | Luna-Muñoz, José^{a; *}

Affiliations: [a] National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán campo 1, UNAM Estado de México, México | [b] Escuela Nacional de Ciencias Biológicas, Depto. Fisiología, Instituto Politécnico Nacional, CDMX, México | [c] School of Engineering and Science, Tecnologico de Monterrey, Toluca, México | [d] CIIDIR, Durango, Instituto Politécnico Nacional, Durango, Becario COFAA, México | [e] Depto. de Patología, Facultad de medicina de la Universidad Autónoma de Nuevo León, Nuevo León, México | [f] Jefa del Servicio de Anatomía Patológicay Citopatología del Hospital Universitario “Dr. José E. González de la UANL, Nuevo León, México | [g] Depto. de Neurocirugía, Centro Especializado en Neurocirugía y Neurociencias, México (CENNM), CDMX, México | [h] School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK | [i] Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA | [j] School of Medicine, Faculty of Health Sciences, Pontificia Universidad Catolica Madre y Maestra, Dominican Republic

Correspondence: [*] Correspondence to: José Luna-Muñoz, National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán campo 1, UNAM Estado de México, México. Tel.: +52 5527080653; E-mail: [email protected]; Mar Pacheco-Herrero, School of Medicine, Faculty of Health Sciences, Pontificia Universidad Catolica Madre y Maestra, Dominican Republic. E-mail: [email protected].

Abstract: We recently developed the National Dementia Biobank in México (BioBanco Nacional de Demencias, BND) as a unit for diagnosis, research, and tissue transfer for research purposes. BND is associated with the Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de Mexico (UNAM), Mexico. The donation of fluids, brain, and other organs of deceased donors is crucial for understanding the underlying mechanisms of neurodegenerative diseases and for the development of successful treatment. Our laboratory research focuses on 1) analysis of the molecular processing of the proteins involved in those neurodegenerative diseases termed tauopathies and 2) the search for biomarkers for the non-invasive and early diagnosis of Alzheimer’s disease.

Keywords: Alzheimer’s disease, amyloid-β , BioBank, brain tissue, neurodegenerative disease, tau protein, tauopathies

DOI: 10.3233/JAD-191015

Journal: Journal of Alzheimer's Disease, vol. 76, no. 3, pp. 853-862, 2020