Can Social Cognition Measurements Differentiate Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease Regardless of Apathy?

Article type: Research Article

Authors: Mariano, Luciano Inácio^{a; b} | Caramelli, Paulo^{a; c} | Guimarães, Henrique Cerqueira^a | Gambogi, Leandro Boson^a | Moura, Millena Vieira Brandão^b | Yassuda, Mônica Sanches^{d; e} | Teixeira, Antônio Lúcio^{f; g} | de Souza, Leonardo Cruz^{a; b; c; *}

Affiliations: [a] Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Instituto de Ciências Biológicas, Pampulha, Belo Horizonte, Minas Gerais (MG), Brazil | [b] Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil | [c] Departamento de Clínica Médica, Faculdade de Medicina, UFMG, Belo Horizonte, MG, Brazil | [d] Grupo de Neurologia Cognitiva e do Comportamento (GNCC), Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Cerqueira César, São Paulo, SP, Brazil | [e] Programa de Pós-Graduação em Gerontologia, Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, São Paulo, SP, Brazil | [f] Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA | [g] Santa Casa BH Ensino e Pesquisa, Santa Efigênia, Belo Horizonte, MG, Brazil

Correspondence: [*] Correspondence to: Leonardo Cruz de Souza, Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190/sl 243, Belo Horizonte, MG, Brazil, CEP 30.130-100. Tel.: +55 31 3409 807; E-mail: [email protected].

Abstract: Background:Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) share cognitive and behavioral symptoms, such as apathy. Social cognition measurements are useful in distinguishing bvFTD from AD, but their accuracies may be affected by apathy. Objective:To investigate whether social cognition measurements can distinguish bvFTD from either apathetic or non-apathetic AD patients. Methods:Three groups of participants were enrolled in the present study: bvFTD (n = 22), AD (n = 20), and healthy controls (HC, n = 23). The AD group was divided into apathetic (n = 10) and non-apathetic (n = 10). All subjects underwent comprehensive neuropsychological examination, including the short version of the Social and Emotional Assessment (Mini-SEA), which comprises the facial emotion recognition test and the faux-pas recognition test (Faux-Pas Test). Apathy was assessed according to the Starkstein’s Apathy (SA) Scale. Results:The bvFTD and AD groups did not differ on global cognitive efficiency and on executive functions. In comparison to the whole AD group, bvFTD displayed lower Faux-Pas Test and Mini-SEA scores. Both AD subgroups, apathetic or non-apathetic, exhibited similar performance on all social cognition measurements. In comparison to either apathetic AD or non-apathetic AD, bvFTD patients underperformed on the Faux-Pas Test and on the Mini-SEA. The area under the curve values for the Mini-SEA total score were 0.87 (bvFTD versus AD), 0.90 (bvFTD versus apathetic AD), and 0.83 (bvFTD versus non-apathetic AD). Conclusion:Social cognition tests provide accurate distinction between bvFTD against either apathetic AD or non-apathetic AD. Social cognition measurements did not correlate with apathy severity.

Keywords: Alzheimer’s disease, apathy, frontotemporal dementia, social cognition

DOI: 10.3233/JAD-190861

Journal: Journal of Alzheimer's Disease, vol. 74, no. 3, pp. 817-827, 2020