Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Issue title: Alzheimer’s Disease: New Beginnings
Guest editors: G. Perry, J. Avila, P.I. Moreira, A.A. Sorensen and M. Tabaton
Article type: Review Article
Authors: Quinn, Joseph F.; *
Affiliations: Oregon Health and Science University, Portland VA Medical Center, Department of Neurology, Portland, OR, USA
Correspondence: [*] Correspondence to: Joseph Quinn, MD, Oregon Health and Science University, Portland VA Medical Center, Department of Neurology, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239, USA. Tel.: +1 503 494 9054; Fax: +1 503 494 9059; E-mail: [email protected].
Abstract: Efforts over the past two decades to develop effective disease-modifying treatments for Alzheimer’s disease have been disappointing, while parallel efforts in another chronic neurologic disease, multiple sclerosis, have been remarkably productive. In an effort to advance development of therapeutics for Alzheimer’s disease, these two fields are contrasted in terms of the utility of animal models, definition of study populations, and utility of biomarkers. Possible solutions are suggested, and the review concludes with description of some active peer-reviewed, publicly funded clinical studies which address some of the identified weaknesses in past clinical trials for age-related dementia.
Keywords: Alzheimer’s disease, animal models, clinical trials
DOI: 10.3233/JAD-179930
Journal: Journal of Alzheimer's Disease, vol. 64, no. s1, pp. S33-S39, 2018
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]