Blood Inflammatory Mediators and Cognitive Decline in Alzheimer’s Disease: A Two Years Longitudinal Study

Article type: Short Communication

Authors: Julian, Adrien^{a; b; c; *} | Rioux-Bilan, Agnès^c | Ragot, Stéphanie^d | Krolak-Salmon, Pierre^e | Berrut, Gilles^f | Dantoine, Thierry^g | Hommet, Caroline^h | Hanon, Olivierⁱ | Page, Guylène^{c; 1} | Paccalin, Marc^{a; c; d; j; 1}

Affiliations: [a] Poitiers University Hospital, Centre Mémoire de Ressources et de Recherche, France | [b] Department of Neurology, Poitiers University Hospital, France | [c] University of Poitiers, EA3808 Molecular Targets and Therapeutic of Alzheimer’s disease, Poitiers, France | [d] Poitiers University Hospital, Centre d’Investigation Clinique, France | [e] Lyon University Hospital, Centre Mémoire de Ressources et de Recherche, France | [f] Department of Geriatrics, Nantes University Hospital, France | [g] Department of Geriatrics, Limoges University Hospital, France | [h] Tours University Hospital, Centre Mémoire de Ressources et de Recherche, France | [i] Department of Geriatrics, Paris Broca University Hospital, France | [j] Department of Geriatrics, Poitiers University Hospital, France

Correspondence: [*] Dr. Adrien Julian, MD, EA3808 Molecular Targets and Therapeutics of Alzheimer’s disease, Pôle Biologie Santé, 1 Rue Georges Bonnet, TSA 51106, 86073 Poitiers Cedex 9, France. E-mail: [email protected].

Note: [1] Co-last authors.

Abstract: Peripheral inflammatory processes are involved in Alzheimer’s disease (AD). We aimed to determine whether plasma inflammatory mediator levels at diagnosis are associated with cognitive decline through a 2-year follow-up in AD patients. Patients (n = 109, mean age 79.44 (6.82) years) were included at diagnosis with MMSE scores between 16 and 25, with C-reactive protein <10 mg/L, and without any acute or chronic inflammation status. Plasma IL-1β, IL-6, TNF-α, and CCL5 were measured using Luminex X-MAP technology at baseline, and after one year and two years of follow-up. The mean values of IL-1β, IL-6, TNF-α, and CCL5 at diagnosis were 0.3, 1.94, 6.57, and 69,615.81 pg/mL, respectively. Mean cognitive decline in MMSE was 3.35 points. No correlation between plasmatic value of IL-1β, IL-6, TNF-α, or CCL5 at diagnosis and cognitive decline during the two years of follow-up was found. Cognitive decline in AD does not appear to be predictable by the tested inflammatory mediators.

Keywords: Alzheimer’s disease, cognitive decline, cytokines, inflammation

DOI: 10.3233/JAD-171131

Journal: Journal of Alzheimer's Disease, vol. 63, no. 1, pp. 87-92, 2018