Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Fattoretti, Patriziaa; 1 | Malavolta, Marcob; 1 | Fabbietti, Paoloc | Papa, Robertad; * | Giacconi, Robertinab | Costarelli, Laurae | Galeazzi, Robertae | Paoloni, Cristinaf | Postacchini, Demetriof | Lattanzio, Fabriziag | Giuli, Cinziaf
Affiliations: [a] Cellular Bioenergetics Laboratory, Center for Neurobiology of Aging, INRCA-IRCCS, Ancona, Italy | [b] Advanced Technology Center for Aging Research, INRCA-IRCCS, Ancona, Italy | [c] Unit of Geriatric Pharmacoepidemiology, INRCA-IRCCS, Cosenza, Italy | [d] Centre of Socio-Economic Gerontological Research, INRCA-IRCCS, Ancona, Italy | [e] Clinical Laboratory and Molecular Diagnostics, INRCA-IRCCS, Ancona, Italy | [f] Geriatrics Operative Unit, INRCA-IRCCS, Fermo, Italy | [g] Scientific Direction, INRCA-IRCCS, Ancona, Italy
Correspondence: [*] Correspondence to: Roberta Papa, INRCA-IRCCS, Via S. Margherita 5, 60121 Ancona, Italy. Tel.: +39 0718004602; Fax: +39 07135941; E-mail: [email protected].
Note: [1] These authors contributed equally to this work.
Abstract: Background:Biomarkers of oxidative stress have been associated with cognitive status in humans and have been proposed to guide prognosis/treatment in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Objective:The aim of this study was to compare oxidative stress status in the plasma of mild-moderate AD, MCI, and healthy elderly with normal cognition (HE) undergoing a non-pharmacological intervention including multi-modal cognitive training (“My Mind Project”). Methods:A prospective randomized trial involving 321 elderly people enrolled in Marche Region, Italy. Each subject was randomly assigned to an experimental (cognitive training) or to a control group. Cognitive performances and biomarkers have been analyzed before intervention (baseline), immediately after termination (follow-up 1), after 6 months (follow-up 2), and after 2 years (follow-up 3). The biological antioxidant potential (BAP) to Diacron reactive oxygen metabolites (d-ROM) ratio has been used as an indicator of oxidative stress status and as outcome variable. Results:We have found no differences in the oxidative status among AD, MCI, and HE. Neither did we find a significant effect of the intervention within experimental groups. Gender was the sole factor with a strong significant effect on BAP/d-ROM. Conclusions:Based on these results, the utility of biomarkers of oxidative stress to guide prognosis/treatment in AD or MCI seems to be limited by lack of specificity, large interindividual variability, and gender bias.
Keywords: Aging, Alzheimer’s disease, cognitive dysfunction, oxidative stress
DOI: 10.3233/JAD-171117
Journal: Journal of Alzheimer's Disease, vol. 63, no. 4, pp. 1405-1414, 2018
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]