Human Gut Microbiota in Health and Alzheimer’s Disease

Article type: Review Article

Authors: Szablewski, Leszek^{; *}

Affiliations: Medical University of Warsaw, Department of General Biology and Parasitology, Warsaw, Poland

Correspondence: [*] Correspondence to: Leszek Szablewski, Medical University of Warsaw, Chair and Department of General Biology and Parasitology, 5 Chalubinskiego Str, 02-004 Warsaw, Poland. Tel.: +48 22 621 26 07; Fax: +48 22 628 53 50; E-mail: [email protected].

Abstract: Gut microbiota plays a crucial role in human health and disease. The alterations in the composition of gut microbiota may cause the onset of certain human pathologies. One of these is Alzheimer’s disease (AD). High-fat diets, administration of antibiotics, lack of probiotics and/or prebiotics in diet increase the risk of AD. On the other hand, modulation of the composition of gut microbiota may decrease the risk of AD and be able to slow down the progression of AD.

Keywords: Alzheimer’s disease, dysbiosis, gut microbiota, metabolic endotoxemia, physiology

DOI: 10.3233/JAD-170908

Journal: Journal of Alzheimer's Disease, vol. 62, no. 2, pp. 549-560, 2018