Affiliations: [a]
University of Lille, CNRS, CHU Lille, UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, Lille, France
| [b] Unité de Gériatrie, Centre Hospitalier de Tourcoing, Tourcoing, France
| [c] Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD, USA
Correspondence:
[*]
Correspondence to: Mohamad El Haj, Laboratoire SCALab UMR CNRS 9193- University of Lille, Domaine du Pont de Bois, 59653 Villeneuve d’Ascq, France. E-mail: [email protected].
Abstract: Relatively to “standard” prospective memory, i.e., remembering to perform a future action, little is known about negative prospective memory, i.e., remembering not to perform a future action. This study investigated the latter ability in Alzheimer’s disease (AD). AD participants and healthy older adults were asked to click on the keyboard or not to click on it when a cue word was encountered. Results showed more omissions (i.e., forgetting to click the keyboard when the instruction was to do so) in AD participants than in healthy older adults, suggesting a prospective memory deficit. Interestingly, more commissions (i.e., clicking the keyboard when the instruction was not to do so) were also observed in AD participants than in healthy older adults. Similar levels of commissions and omissions were observed in AD participants and in healthy older adults. Also, commissions and omissions were correlated with performance on an inhibition assessment task. Our findings reveal that AD is characterized by not only difficulty in the retrieval of recent information, but also difficulty to inhibit no-longer appropriate stimulus-response associations previously learned, suggesting a specific deficit of negative prospective memory in AD.
