Kidins220 Correlates with Tau in Alzheimer’s Disease Brain and Cerebrospinal Fluid

Article type: Short Communication

Authors: Gamir-Morralla, Andrea^{a; d} | Belbin, Olivia^{b; d} | Fortea, Juan^{b; d} | Alcolea, Daniel^{b; d} | Ferrer, Isidro^{c; d} | Lleó, Alberto^{b; d} | Iglesias, Teresa^{a; d; *}

Affiliations: [a] Instituto de Investigaciones Biomédicas “Alberto Sols”, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain | [b] Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain | [c] Instituto de Neuropatología, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain | [d] CIBERNED, Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain

Correspondence: [*] Correspondence to: Teresa Iglesias, Department of Endocrine and Nervous System Physiopathology, Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), C/ Arturo Duperier, 4, Madrid 28029, Spain. Tel.: +34 915854487; Fax: +34 915854401; E-mail: [email protected].

Abstract: Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer’s disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, in the brain and cerebrospinal fluid (CSF) of controls and AD patients. Only the N-terminal antibody showed a positive correlation between Kidins220 and phosphorylated tau in AD brains. Using this antibody, Kidins220 was detected in CSF from AD patients where it positively correlated with CSF phosphorylated tau and tau. This study highlights the potential of Kidins220 as a CSF biomarker in AD.

Keywords: Alzheimer’s disease, amyloid, antibody, ARMS, biomarkers, calpain, cerebrospinal fluid, excitotoxicity, Kidins220, tau protein

DOI: 10.3233/JAD-160639

Journal: Journal of Alzheimer's Disease, vol. 55, no. 4, pp. 1327-1333, 2017