Examining the Relationship Between Autobiographical Memory Impairment and Carer Burden in Dementia Syndromes

Article type: Research Article

Authors: Kumfor, Fiona^{a; b; c} | Teo, Drusilla^{a; b} | Miller, Laurie^{c; d; e} | Lah, Suncica^{c; f} | Mioshi, Eneida^g | Hodges, John R.^{a; b; c} | Piguet, Olivier^{a; b; c} | Irish, Muireann^{a; c; h; *}

Affiliations: [a] Neuroscience Research Australia, Sydney, Australia | [b] School of Medical Sciences, the University of New South Wales, Sydney, Australia | [c] ARC Centre of Excellence in Cognition and its Disorders, Sydney, Australia | [d] Neuropsychology Unit, Royal Prince Alfred Hospital, Sydney, Australia | [e] Central Clinical School, The University of Sydney, Sydney, Australia | [f] School of Psychology, University of Sydney, Sydney, Australia | [g] Department of Psychiatry, University of Cambridge, Cambridge, UK | [h] School of Psychology, The University of New South Wales, Sydney, Australia

Correspondence: [*] Correspondence to: Dr. Muireann Irish, Neuroscience Research Australia, P.O. Box 1165, Randwick, NSW 2031, Australia. Tel.: +61 2 9399 1602; Fax: +61 2 9399 1047; E-mail: [email protected].

Abstract: Background:Autobiographical memory (ABM) refers to the capacity to remember one’s own past, and is known to be central for supporting one’s identity and sense of self. This capacity is commonly affected in Alzheimer’s disease (AD), as well as semantic dementia (SD) and behavioral-variant frontotemporal dementia (bvFTD). Importantly, ABM plays a critical social function, facilitating relationship intimacy and empathy, and thus loss of ABM may also negatively affect families and carers. Objective:To explore the relationship between ABM disruption and carer burden in AD, SD, and bvFTD, and establish whether characteristic ABM profiles differentially relate to carer burden across dementia syndromes. Methods:We recruited 12 AD, 10 SD, and 13 bvFTD patients and their primary carer. All participants completed the Autobiographical Interview to assess memory for recent and remote events. Carers completed: the Zarit Burden Interview; Depression, Anxiety and Stress Scale (DASS-21); and the Intimate Bond Measure (IBM). Results:In AD, loss of recent ABM was associated with worse psychological wellbeing of carers on the DASS-21. In contrast in SD, remote ABM dysfunction was associated with SD patients showing greater controlling behavior within their intimate relationships. In bvFTD, surprisingly, despite pervasive ABM impairment, no relationship between extent of ABM loss and carer burden was observed. Conclusion:These preliminary results reveal that ABM impairment impacts on patients’ families and carers and suggest that these influences vary according to the pattern of ABM dysfunction. Disease-specific interventions focusing on preserved aspects of ABM may improve quality of life for both patients and carers.

Keywords: Alzheimer’s disease, frontotemporal dementia, quality of life, relationships, semantic dementia, wellbeing

DOI: 10.3233/JAD-150740

Journal: Journal of Alzheimer's Disease, vol. 51, no. 1, pp. 237-248, 2016