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Nutrition and the Prevalence of Dementia in Mainland China, Hong Kong, and Taiwan: An Ecological Study

Article type: Research Article

Authors: Wu, Yu-Tzua; * | Grant, William B.b | Prina, A. Matthewc | Lee, Hsin-yid | Brayne, Carola

Affiliations: [a] Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK | [b] Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA | [c] King's College London, Institute of Psychiatry, Centre for Global Mental Health, Health Service and Population Research Department, De Crespigny Park, Denmark Hill, London, UK | [d] Luke International (Norway) - Malawi Office, Mzuzu, Malawi

Correspondence: [*] Correspondence to: Yu-Tzu Wu, Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK. Tel.: +44 1223 330321; E-mail: [email protected].

Keywords: China, ecological study, prevalence of dementia, nutrition

DOI: 10.3233/JAD-141926

Journal: Journal of Alzheimer's Disease, vol. 44, no. 4, pp. 1099-1106, 2015

Accepted 13 October 2014
|
Published: 19 February 2015
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Supplementary Materials:

Supplementary Table 1.

Abstract

Background:

Western diets are associated with obesity, vascular diseases, and metabolic syndrome and might increase dementia risk in later life. If these associations are causal, those low- and middle-income countries experiencing major changes in diet might also see an increasing prevalence of dementia.

Objective:

To investigate the relationship of dietary supply and the prevalence of dementia in mainland China, Hong Kong, and Taiwan over time using existing data and taking diagnostic criteria into account.

Methods:

Estimated total energy supply and animal fat from the United Nations was linked to the 70 prevalence studies in mainland China, Hong Kong, and Taiwan from 1980 to 2012 according to the current, 10 years, and 20 years before starting year of investigation. Studies using newer and older diagnostic criteria were separated into two groups. Spearman's rank correlation was calculated to investigate whether trends in total energy, animal fat supply, and prevalence of dementia were monotonically related.

Results:

The supply of total energy and animal fat per capita per day in China increased considerably over the last 50 years. The original positive relationship of dietary supply and dementia prevalence disappeared after stratifying by newer and older diagnostic criteria and there was no clear time lag effect.

Conclusion:

Taking diagnostic criteria into account, there is no cross-sectional or time lag relationship between the dietary trends and changes in dementia prevalence. It may be too early to detect any such changes because current cohorts of older people did not experience these dietary changes in their early to mid-life.

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