Cerebrovascular Markers in Lowered Cognitive Function

Issue title: Alzheimer's Disease: Detection, Prevention, and Preclinical Treatment

Guest editors: Jack C. de la Torre

Article type: Review Article

Authors: Mataró, Maria^{a; b; *} | Soriano-Raya, Juan José^a | López-Olóriz, Jorge^{a; b} | Miralbell, Júlia^{a; b} | Dacosta-Aguayo, Rosalia^{a; c}

Affiliations: [a] Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain | [b] Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Spain | [c] Group of Computer Science and Artificial Intelligence, University of the Basque Country, San Sebastian, Spain

Correspondence: [*] Correspondence to: Maria Mataró, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Spain. Fax: +34 93 402 15 84; E-mail: [email protected].

Abstract: Cerebrovascular disease (CVD) is a major cause of age-related cognitive decline and dementia. The identification of cognitive-related cerebrovascular markers is crucial in the early detection of individuals at high risk of cognitive decline. In vivo markers of CVD can help to characterize the underlying pathology, stage the progression of the disease, as well as identify and monitor candidates who could benefit from preventive interventions. We review the most common cerebrovascular markers of cognitive decline in subclinical individuals. These include neuroimaging, sonographic, and blood markers.

Keywords: Biomarkers, blood markers, cerebrovascular disease, cognitive impairment, MRI markers, sonographic markers

DOI: 10.3233/JAD-141443

Journal: Journal of Alzheimer's Disease, vol. 42, no. s4, pp. S383-S391, 2014