Arterial Wall Function is Associated with Cognitive Performance Primarily in Elderly with Type 2 Diabetes

Article type: Research Article

Authors: Ravona-Springer, Ramit^{a; b; *} | Haratz, Salo^{b; c} | Tanne, David^{b; c} | Schmeidler, James^d | Efrati, Shai^{b; e; f; g} | Rosendorff, Clive^{h; i} | Beeri, Michal Schnaider^{d; j; 1} | Silverman, Jeremy M.^{d; h; 1}

Affiliations: [a] Memory Clinic, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel | [b] Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel | [c] Stroke Unit, Neurology Department, Sheba Medical Center, Ramat Gan, Israel | [d] Department of Psychiatry at the Icahn School of Medicine at Mount Sinai, New York, NY, USA | [e] The institute of Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin, Israel | [f] Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel | [g] Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel | [h] James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA | [i] Department of Medicine, (Cardiology), Mount Sinai School of Medicine, New York, NY, USA | [j] Josef Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel

Correspondence: [*] Correspondence to: Ramit Ravona-Springer, MD, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel. Tel.: +972 54 2550676; Fax: +972 3 5346628; E-mails: [email protected], and [email protected].

Note: [1] Joint co-authors; These authors contributed equally to this work.

Abstract: Regression analyses compared 41 type 2 diabetes (T2D) and 131 non-T2D cognitively normal elderly males on the associations of arterial wall function measures [large artery elasticity index (LAEI), small artery elasticity index (SAEI), systemic vascular resistance (SVR), and total vascular impedance (TVI)] with cognitive performance (memory, language, and executive functions), controlling for socio-demographic and cardiovascular factors. Higher LAEI and lower TVI were significantly associated with better executive functions performance in T2D but not in non-T2D subjects. Lower TVI was more associated with better language performance in T2D. Results suggest that arterial wall function is associated with cognition in T2D.

Keywords: Arterial wall function, cognitive function, large artery elasticity index, total vascular impedance, type 2 diabetes

DOI: 10.3233/JAD-141197

Journal: Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 687-693, 2015