Affiliations: [a] Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, China | [b] Department of Endocrinology, Xiang-Ya Hospital, Central South University, Changsha, China | [c] Institute of Clinical Medicine, People's Pospital of Hunan Province, The First Affiliated Hospital of Hunan Normal University, Changsha, China | [d] Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI-Alzheimer's Disease Research Center, Novum, Huddinge, Sweden
Correspondence:
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Correspondence to: Jin-Jing Pei, MD, PhD, Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI-Alzheimer's Disease Research Center, Novum, S-141 86 Huddinge, Sweden. E-mail: [email protected].
Abstract: Recent evidence implicated aberrant mammalian target of rapamycin (mTOR)-dependent signaling in both Alzheimer's disease (AD) and brain tumors. This review focuses on the potential mechanisms shared by both neurodegeneration and carcinogenesis. In particular, attention was paid to the possible roles of mTOR-dependent signaling in these two fundamental pathophysiological processes. We hypothesize that common stresses could lead either to progressive degeneration or uncontrolled carcinogenesis via cell type specific upregulation of mTOR-dependent signaling in the central nervous system while mTOR-mediated carcinogenesis might permit glial cells to escape from degeneration.
