Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

Article type: Research Article

Authors: Chien, David T.^a | Szardenings, A. Katrin^a | Bahri, Shadfar^b | Walsh, Joseph C.^a | Mu, Fanrong^a | Xia, Chunfang^a | Shankle, William R.^c | Lerner, Alan J.^d | Su, Min-Ying^b | Elizarov, Arkadij^a | Kolb, Hartmuth C.^{a; *}

Affiliations: [a] Siemens Molecular Imaging, Inc., Culver City, CA, USA | [b] Tu and Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, CA, USA | [c] Shankle Clinic Memory and Cognitive Disorders Program, Hoag Neurosciences Institute, Newport Beach, CA, USA | [d] University Hospitals – Case Medical Center, Department of Neurology, Cleveland, OH, USA

Correspondence: [*] Correspondence to: Hartmuth C. Kolb, Siemens Molecular Imaging, Inc., 6100 Bristol Parkway, Culver City, CA 90230, USA. Tel.: +1 310 804 7324; Fax: +1 310 744 4879; E-mail: [email protected].

Keywords: Alzheimer's disease, amyloid-β, brain imaging, mild cognitive impairment, molecular imaging, neurofibrillary tangles, PHF-tau, tau, tau aggregates, tauopathy

DOI: 10.3233/JAD-130098

Journal: Journal of Alzheimer's Disease, vol. 38, no. 1, pp. 171-184, 2014