Affiliations: [a] Department of Neurosciences, University of California, San Diego, CA, USA | [b] Department of Pathology, University of California, San Diego, CA, USA
Correspondence:
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Correspondence to: Eliezer Masliah, MD, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA. Tel.: +1 858 534 8992; Fax: +1 858 534 6232; E-mail: [email protected].
Abstract: Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory deficits and other cognitive disturbances. Neuropathologically, AD is characterized by the progressive loss of basal forebrain cholinergic neurons that innervate the hippocampus and cortex and the abnormal extracellular accumulation of amyloid-β and intracellular tau protein. Current research on AD is focused on the mechanisms underlying the abnormal oligomerization, fibrillation, and accumulation of the amyloid-β and tau proteins, mechanisms that may alter the dynamics of this accumulation and on experimental therapeutics approaches aimed at the clearance of the abnormally folded proteins and other potentially neuroprotective interventions. This review will summarize the main areas of investigation in AD and present ways forward for future work.
