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Issue title: Alzheimer's Disease: Advances for a New Century
Guest editors: George Perry, Xiongwei Zhu, Mark A. Smith, Aaron Sorensen and Jesús Avila
Article type: Review Article
Authors: Alafuzoff, Irinaa; b; c; *
Affiliations: [a] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden | [b] Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland | [c] Department of Clinical Pathology and Cytology, Laboratory Medicine, Uppsala University Hospital, Uppsala, Sweden
Correspondence: [*] Correspondence to: Prof. Irina Alafuzoff, MD, PhD, Department of Immunology, Uppsala University/Uppsala University Hospital, Genetics and Pathology, Dag Hammarskjölds väg 20, 751 85 Uppsala, Sweden. Fax: +46 18 553354; E-mail: [email protected].
Abstract: The invitation to contribute to “Alzheimer's Disease: Advances for a New Century” gave me an opportunity to briefly summarize my personal opinions about how the field of neuropathology has evolved. The goal is to briefly exemplify the changes that have influenced the way we conduct our diagnostic work as well as the way we interpret our results. From an era of histological stains, we have moved to visualization of altered proteins in predicted brain regions; we have also realized that in many aged subjects, not one but a plethora of co-pathologies are seen, and finally, we have become aware that the degenerative process is initiated much earlier than we ever suspected.
Keywords: Aging, Alzheimer's disease-related pathology, amyloid-β, co-morbidity, hyperphosphorylated tau, immunohistochemistry, neuropathology, α-synuclein
DOI: 10.3233/JAD-2012-129024
Journal: Journal of Alzheimer's Disease, vol. 33, no. s1, pp. S173-S179, 2013
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