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Article type: Research Article
Authors: Li, Hea; b; 1 | Liang, Yinga; 1 | Chen, Keweic | Li, Xina | Shu, Nia; * | Zhang, Zhanjuna; * | Wang, Yongyanb | for the BGBH Study Group2
Affiliations: [a] State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, P.R. China | [b] Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P.R. China | [c] Computational Image Analysis Banner Alzheimer's Institute, Phoenix, AZ, USA
Correspondence: [*] Correspondence to: Zhanjun Zhang, MD, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China. Tel.: +86 1058802005; Fax: +86 1058802005; E-mail: [email protected]; Ni Shu, PhD, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China. Tel.: +86 1058804482; Fax: +86 1058804482; E-mail: [email protected].
Note: [1] These authors contributed equally to the manuscript.
Note: [2] For the Beijing Ageing Brain Rejuvenation Initiative Study Group Members: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University; Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine; Department of Neurology, Beijing Hospital of Ministry of Health, Beijing Hospital; Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, China.
Abstract: Amnestic mild cognitive impairment (aMCI) is recognized as the prodromal phase of Alzheimer's disease (AD). Evidence showed that patients with multiple-domain (MD) aMCI were at higher risk of converting to dementia and exhibited more severe gray matter atrophy than single-domain (SD) aMCI. The investigation of the microstructural abnormalities of white matter (WM) among different subtypes of aMCI and their relations with cognitive performances can help to understand the variations among aMCI subtypes and to construct potential imaging based biomarkers to monitor the progression of aMCI. Diffusion-weighted MRI data were acquired from 40 patients with aMCI (aMCI-SD: n = 19; aMCI-MD: n = 21) and 37 healthy controls (HC). Voxel-wise and atlas-based analyses of whole-brain WM were performed among three groups. The correlations between the altered diffusion metrics of the WM tracts and the neuropsychological scores in each subtype of aMCI were assessed. The aMCI-MD patients showed disrupted integrity in multiple WM tracts across the whole-brain when compared with HCs or with aMCI-SD. In contrast, only few WM regions with diffusion changes were found in aMCI-SD as compared to HCs and with less significance. For neuropsychological correlations, only aMCI-MD patients exhibited significant associations between disrupted WM connectivity (in the body of the corpus callosum and the right anterior internal capsules) and cognitive impairments (MMSE and Digit Symb-Coding scores), whereas no such correlations were found in aMCI-SD. These findings indicate that the degeneration extensively exists in WM tracts in aMCI-MD that precedes the development of AD, whereas underlying WM pathology in aMCI-SD is imperceptible. The results are consistent with the view that aMCI is not a uniform disease entity and presents heterogeneity in the clinical progression.
Keywords: Amnestic mild cognitive impairment, diffusion tensor imaging, multiple-domain, single-domain, TBSS, white matter
DOI: 10.3233/JAD-122023
Journal: Journal of Alzheimer's Disease, vol. 36, no. 2, pp. 365-376, 2013
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