The MTHFD1L Gene rs11754661 Marker is Not Associated with Alzheimer's Disease in a Sample of the Spanish Population

Article type: Short Communication

Authors: Ramírez-Lorca, Reposo^a | Boada, Mercé^{b; c} | Antúnez, Carmen^{d; e} | López-Arrieta, Jesús^f | Moreno-Rey, Concha^a | Hernández, Isabel^b | Marín, Juan^d | Gayán, Javier^a | González-Pérez, Antonio^a | Alegret, Montserrat^b | Tárraga, Lluis^b | Real, Luis M.^a | Ruiz, Agustín^{a; *}

Affiliations: [a] Department of Structural Genomics, NeoCodex, Sevilla, Spain | [b] Memory Clinic of Fundació ACE, Institut Catalá de Neurciéncies Aplicades, Barcelona, Spain | [c] Hospital Universitari Vall d'Hebron – Institut de Recerca, Universitat Autónoma de Barcelona (VHIR-UAB), Barcelona, Spain | [d] Dementia Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain | [e] Alzheimur Foundation, Murcia, Spain | [f] Memory Unit, University Hospital La Paz-Cantoblanco, Madrid, Spain

Correspondence: [*] Correspondence to: Dr. Agustín Ruiz, Department of Structural Genomics, Neocodex SL, Avda. Charles Darwin 6, Acceso A. Parque Científico y Tecnológico Isla de la Cartuja, 41092-Seville, Spain. Tel.: +34 65781907; Fax: +34 955047325; E-mail: [email protected].

Abstract: The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome Association Study [1]. We have carried out an independent study of this genetic variant in 2467 individuals from Spain. We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.

Keywords: Folate, GWAS, homocysteine, MTHFD1L, population genetics, susceptibility, SNP

DOI: 10.3233/JAD-2011-101983

Journal: Journal of Alzheimer's Disease, vol. 25, no. 1, pp. 47-50, 2011