Cohort profile: Epidemiological Clinicopathological Studies in Europe (EClipSE)

Issue title: Mini-Forum: Clinical-Pathologic Correlations in Population- and Community-Based Studies of Brain Aging

Guest editors: Thomas Montine and Joshua Sonnen

Article type: Research Article

Authors: Members EClipSE Collaborative^{; *}

Affiliations: University of Cambridge, Robinson Way, Cambridge UK CB2 0SR

Correspondence: [*] Address for correspondence: Dr. Hannah Keage, Institute of Public Health, University of Cambridge, Robinson Way, Cambridge UK CB2 0SR. Tel.: +44 1223 763 837; Fax: +44 1223 741 339; E-mail: [email protected].

Abstract: Epidemiological Clinicopathological Studies in Europe (EClipSE) is the harmonization of neuropathological and longitudinal clinical data from three population-based prospective longitudinal studies of aging. The EClipSE database (Version 1.0) comprises data from the first 970 people who donated their brain at death and this number will increase. EClipSE enables sociodemographic, health, cognitive, and genetic measures collected during life to be related to neuropathology at death, testing hypotheses which require more power than has been previously possible. EClipSE aims to help throw light on relationships between biological, health and psychological factors underlying ageing and the manifestation of clinical dementia.

Keywords: AAging, brain, dementia, epidemiology, health, population

DOI: 10.3233/JAD-2009-1181

Journal: Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 659-663, 2009