The Relationship Between Memory Complaints, Perceived Quality of Life and Mental Health in Apolipoprotein Eε4 Carriers and Non-Carriers

Article type: Research Article

Authors: Sohrabi, Hamid R.^{a; b} | Bates, Kristyn A.^{a; b; c} | Rodrigues, Mark^{a; b; c} | Taddei, Kevin^{a; b; c} | Martins, Georgia^{a; b; c} | Laws, Simon M.^{c; d} | Lautenschlager, Nicola T.^{a; e; f} | Dhaliwal, Satvinder S.^g | Foster, Jonathan K.^{b; c} | Martins, Ralph N.^{a; b; c; *}

Affiliations: [a] The School of Psychiatry and Clinical Neuroscience, University of Western Australia, WA, Australia | [b] The Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Australia | [c] The School of Exercise, Biomedical and Health Science, Edith Cowan University, WA, Australia | [d] The Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen (TU-Munchen), Munchen, Germany | [e] West Australian Centre for Health & Ageing, University of Western Australia, WA, Australia | [f] Academic Unit for Psychiatry of Old Age, St Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia | [g] The School of Public Health, Curtin University of Technology, WA, Australia

Correspondence: [*] Corresponding author: Professor Ralph N. Martins, School of Exercise, Biomedical and Health Science, Edith Cowan University, 100 Joondalup Dr, Joondalup, WA 6027, Australia, Tel.: +61 08 6304 5456; Fax: +61 08 6304 5851; E-mail: [email protected].

Abstract: Apolipoprotein E ε4 (APOE-ε4) is a major genetic risk factor for Alzheimer's disease. In this study, we addressed the question of whether possession of the APOE-ε4 allele results in adverse effects on perceived health-related quality of life (HRQL) and on symptoms of depression and anxiety in people with subjective memory complaints (SMC). 138 healthy, community-dwelling elderly volunteers, aged 52 to 85, were assessed for HRQL, depression, and anxiety. The participants were classified as i) APOE-ε4 carriers or ii) non-carriers with a) SMC or b) without memory complaints. The possible interactions of APOE genotype, gender, and SMC on HRQL, depression, and anxiety were investigated statistically. SMC was significantly associated with poorer outcomes on measures of depression, trait anxiety, and mental health. APOE-ε4 carriers did not significantly differ from non-carriers on HRQL, depression, and anxiety. However, significant interaction was found between APOE-ε4 genotype and SMC on depression. These findings are important from a health perspective and suggest that memory complaints are associated with markers of mental health and quality of life that are independent of possession of the APOE-ε4 allele, despite the importance of this polymorphism in the risk of AD and other health problems.

Keywords: Alzheimer's disease, anxiety, APOE-ε4, depression, health-related quality of life (HRQL), subjective memory complaints

DOI: 10.3233/JAD-2009-1018

Journal: Journal of Alzheimer's Disease, vol. 17, no. 1, pp. 69-79, 2009