Affiliations: Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders-Brown Center on Aging and Alzheimer's Disease Center, University of Kentucky, Lexington, KY, USA
Correspondence:
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Corresponding author: Peter T. Nelson, M.D., Ph.D., Department of Pathology, Division of Neuropathology, and the Sanders-Brown Center on Aging, Rm 311, Sanders-Brown Building, 800 S. Limestone, University of Kentucky, Lexington, KY 40536-0230, USA. Tel.: +1 859 257 1412 x254; Fax: +1 859 257 6054; E-mail: [email protected].
Note: [] Communicated by Thomas Montine
Abstract: Dementia can be caused by different diseases including Alzheimer's disease (AD), dementia with Lewy bodies (DLB), or both (AD + DLB). University of Kentucky AD Center pathologically-diagnosed AD and AD + DLB cases were evaluated who had three or more longitudinal antemortem mental status examinations (n=156). Patients with important concomitant pathology (n=5) or patients that were profoundly demented at recruitment (intake MMSE<20; n=86) were excluded to strengthen our ability to test the association of specific clinical and pathological indices. Patients with pathologically-diagnosed AD + DLB (n=25) lost cognitive capacity faster than patients with AD alone (n=40). In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline.
