Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease

Issue title: Metals in Alzheimer's disease

Guest editors: Andrei C. Miu and Oana Benga

Article type: Research Article

Authors: Platt, Bettina^{; *}

Affiliations: School of Medical Sciences, University of Aberdeen, Scotland, UK | Program of Cognitive Neuroscience, Department of Psychology, Babeş-Bolyai University, Cluj-Napoca, CJ, Romania

Correspondence: [*] Address for correspondence: Dr. Bettina Platt, School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK. Tel.: +44 1224 555741; Fax: +44 1224 555719; E-mail: [email protected].

Abstract: This review highlights advantages and disadvantages of experimental procedures (chemical, cellular, physiological, histochemical and epidemiological) that have been used to identify Alzheimer- and dementia-related targets for exogenous toxins, and discusses how neuronal function can be assessed experimentally, based on the evidence obtained for the neurotoxin aluminium.

Keywords: Hippocampus, toxins, aluminium, behaviour, imaging, immunocytochemistry, electrophysiology, cell death

DOI: 10.3233/JAD-2006-102-307

Journal: Journal of Alzheimer's Disease, vol. 10, no. 2-3, pp. 203-213, 2006