An MRI Brain Atrophy and Lesion Index to Assess the Progression of Structural Changes in Alzheimer's Disease, Mild Cognitive Impairment, and Normal Aging: A Follow-Up Study

Issue title: Imaging the Alzheimer Brain

Guest editors: J. Wesson Ashford, Allyson Rosen, Maheen Adamson, Peter Bayley, Osama Sabri, Ansgar Furst, Sandra E. Black and Michael Weiner

Article type: Research Article

Authors: Zhang, Ningnannan^{a; b} | Song, Xiaowei^{a; c} | Zhang, Yunting^b | Chen, Wei^{a; b} | D'Arcy, Ryan C.N.^{a; d} | Darvesh, Sultan^{e; f} | Fisk, John D.^{e; g} | Rockwood, Kenneth^{c; e; *} | Alzheimer's disease Neuroimaging Initiative

Affiliations: [a] National Research Council Canada Institute for Biodiagnostics (Atlantic), Halifax, NS, Canada | [b] Department of Radiology of the General Hospital, Tianjin Medical University, Tianjin, China | [c] Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS, Canada | [d] Departments of Radiology and Neuroscience, Dalhousie University, Halifax, NS, Canada | [e] Centre for Health Care of the Elderly, QEII Health Sciences Centre, Halifax, NS, Canada | [f] Departments of Medicine (Neurology) and Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada | [g] Departments of Psychiatry, Dalhousie University, Halifax, NS, Canada

Correspondence: [*] Correspondence to: Xiaowei Song, PhD, MSCS, National Research Council Canada, Institute for Biodiagnostics (Atlantic), Neuroimaging Research Laboratory, Suite 3900, 1796 Summer Street, Halifax, NS B3H 3A7, Canada. Tel.: +(902) 4731876; Fax: +(902) 4731851; E-mail: [email protected]. Kenneth Rockwood, MD, FRCPC, Divisions of Geriatric Medicine and Neurology, Department of Medicine, Dalhousie University 1421-5955 Veterans Memorial Lane, Halifax, NS, Canada, B3H 2E1. Tel.: +(902) 473 4886; Fax: +(902) 473 1050; E-mail: [email protected].

Note: [1] Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (www.loni.ucla.edu/ADNI). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. ADNI is the result of efforts of many co-investigators from a broad range of academic institutions and private corporations. The Principal Investigator is Michael W. Weiner, MD, VA Medical Center and University of California - San Francisco. ADNI investigators include complete listing available at http://www.loni.ucla.edu/research/active-investigators.

Keywords: Alzheimer's disease, aging, atrophy, cognition, lesion, visual scale

DOI: 10.3233/JAD-2011-0048

Journal: Journal of Alzheimer's Disease, vol. 26, no. s3, pp. 359-367, 2011