Issue title: Imaging the Alzheimer Brain
Guest editors: J. Wesson Ashford, Allyson Rosen, Maheen Adamson, Peter Bayley, Osama Sabri, Ansgar Furst, Sandra E. Black and Michael Weiner
Article type: Research Article
Authors: Olichney, John M.a; b; * | Yang, Jin-Chena; b | Taylor, Jasonc | Kutas, Martad; e
Affiliations: [a] Department of Neurology, University of California, Davis, CA, USA | [b] Center for Mind and Brain, University of California, Davis, CA, USA | [c] MRC Cognition and Brain Sciences Unit, Cambridge, UK | [d] Department of Cognitive Science, University of California, San Diego, CA, USA | [e] Department of Neurosciences, University of California, San Diego, CA, USA
Correspondence:
[*]
Correspondence to: Prof. John M. Olichney, M.D., Center for Mind and Brain, 267 Cousteau Place, Davis, CA 95618, USA. Fax: +1 530 297 4000; E-mail: [email protected].
Abstract: Cognitive event-related brain potential (ERP) studies of decision-making and attention, language, and memory impairments in Alzheimer's disease (AD) and mild cognitive impairment (MCI) are reviewed. Circumscribed lesions of the medial temporal lobe (MTL), as may be the case in individuals with amnestic MCI, generally produce altered plasticity of the late positive P600 component, with relative sparing of earlier sensory ERP components. However, as the neuropathology of AD extends to neocortical association areas, abnormalities of the P300 and N400 (and perhaps even P50) become more common. Critically, ERP studies of individuals at risk for AD may reveal neurophysiological changes prior to clinical deficits, which could advance the early detection and diagnosis of “presymptomatic AD”.
Keywords: Alzheimer's disease (AD), mild cognitive impairment (MCI), synaptic dysfunction, preclinical AD, event-related potentials (ERP), P300, N400, P600, Late Positive Component (LPC), EEG
DOI: 10.3233/JAD-2011-0047
Journal: Journal of Alzheimer's Disease, vol. 26, no. s3, pp. 215-228, 2011
Published: 4 October 2011
