Affiliations: [a] Department of Pathology, University of Washington, Seattle, WA, USA | [b] Department Neurology, Oregon Health and Sciences University, Portland, OR, USA | [c] Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN, USA
Correspondence:
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Corresponding author: Thomas J. Montine, MD, PhD, University of Washington, Department of Pathology, Box 359791, Harborview Medical Center, 325 9th Ave, Seattle, WA 98104, USA. Tel.: +1 206 731 4106; Fax: +1 206 341 5249; E-mail: [email protected].
Abstract: We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both α-tocopherol and vitamin C.
