Head trauma and Alzheimer's disease

Article type: Research Article

Authors: Nandoe, Rishi D.S.^a | Scheltens, Philip^{a; *} | Eikelenboom, Piet^b

Affiliations: [a] Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands | [b] Department of Psychiatry, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands

Correspondence: [*] Corresponding author: Philip Scheltens, Dept Neurology, Vrije Universiteit Medisch Centrum, PO Box 7057, 1007 MB Amsterdam, the Netherlands. Tel.: +31 20 444 4444 (ext. 552); Fax: +31 20 444 0715; E-mail: [email protected].

Abstract: The authors describe a case of a 55 year old woman who was diagnosed with Alzheimer's disease 1.5 years after a car accident in which she experienced a mild concussion. Extensive history taking disclosed no cognitive changes prior to the car accident. The case is discussed in view of the inflammation hypothesis regarding Alzheimer's disease and the role of the apolipoprotein E4 genotype of the patient.

Keywords: Alzheimer's disease, head trauma, inflammation, atrophy, cholinesterase inhibitors, ApoE, amyloid

DOI: 10.3233/JAD-2002-4405

Journal: Journal of Alzheimer's Disease, vol. 4, no. 4, pp. 303-308, 2002