Abstract: Whether for the generation or application of evidence to guide
healthcare decisions, the success of evidence-based medicine is grounded in
principles common to engineering. In the Learning Healthcare System envisioned
by the Institute of Medicine's (IOM) Roundtable on Evidence-Based Medicine,
evidence emerges as a natural by-product of care delivery, which is thoroughly
documented, pooled for continuous monitoring and analysis, integrated with
insights from related studies, and fed back seamlessly to improve the
consistency and appropriateness of care decisions by clinicians and their
patients. Drawing from lessons shared at the IOM/NAE symposium,
Engineering a Learning Healthcare System, this paper provides an overview of
the state-of-play in health care today, some of its key challenges, the vision
and features of a learning healthcare system, applicable commonalties and
principles from engineering, and potential collaborative opportunities moving
forward to the benefit of both fields.