Affiliations: School of Life Science, East China Normal University,
Shanghai, China | Institutes for Advanced Interdisciplinary Research,
East China Normal University, Shanghai, China | Department of Otorhinolaryngology, Peking Union
Medical College Hospital, Beijing, China | Central Laboratory, Wuhan Children's Hospital, Wuhan,
Hubei, China | Shanghai Integrated Circuit Research and Development
Center, Shanghai, China
Note: [] Corresponding authors: Yulan Zhao, School of Life
Science, East China Normal University, North Zhongshan Road
#3663, Shanghai 200062, China. Tel.: +86 21 62237225; Fax: +86 21
62237226; E-mail: [email protected]; Wei Zhang, PhD, Institutes for
Advanced Interdisciplinary Research, East China Normal University, North
Zhongshan Road #3663, Shanghai 200062, China. Tel.: +86 21 54344755; Fax:
+86 21 54344755; E-mail: [email protected]
Abstract: BACKGROUND: Recent studies have shown that microRNAs (miRNA) have
prognostic values in cancers. This meta-analysis seeks to summarize the global
predicting role of miR-155 for survival in patients with a variety of
carcinomas. METHODS: Eligible studies were identified through multiple search
strategies. Data were extracted from studies investigating the relationship
between miR-155 expression and survival in cancer patients. Combined hazard
ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were
included for this meta-analysis. For overall survival, higher miR-155
expression could significantly predict worse outcome with the pooled HR of
2.057 (95% CI: 1.392–3.039). For relapse or progress-free survival,
elevated miR-155 was also a significant predictor, with a combined HR of 1.918
(95% CI: 1.311–2.806,). In addition, subgroup analysis showed that higher
expression of miR-155 had the trends to predict worse outcome in lung cancer.
However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a
prognostic value in cancer patients. Regularly measuring miR-155 expression may
be useful in clinical practice.
