Effect of non-surgical periodontal therapy on interleukin-29
levels in gingival crevicular fluid of chronic periodontitis and aggressive
periodontitis patients
Affiliations: Department of Periodontics, Government Dental College,
Hospital and Research Institute, Bangalore, India | Department Of Periodontics, Rajarajeshwari Dental
College and Hospital, Bangalore, India
Note: [] Corresponding author: A.R. Pradeep, Department of
Periodontics, Government Dental College, Hospital and Research Institute,
Bangalore, India. Fax: +91 080 26703176; E-mail:
[email protected]
Abstract: Recently discovered interleukin 29 (IL-29) has antiviral properties
and its production is induced by herpes viruses. This study was aimed at
analyzing the effect of non-surgical periodontal treatment on IL-29 levels in
gingival crevicular fluid (GCF) of chronic and aggressive periodontitis
patients. A total of 60 participants were divided into healthy group (group 1;
n=20), chronic periodontitis group (group 2; n=20), and aggressive
periodontitis group (group 3; n=20). GCF samples collected from each subject at
baseline and 6–8 weeks after scaling and root planing were quantified for
IL-29 levels using ELISA. The mean IL-29 concentration in GCF was found to be
highest in group 3 (92.37 pg/μl). The mean IL-29 level in group 1 and group
2 was 36.88 pg/μl and 69.35 pg/μl respectively. After scaling and root
planing, the mean concentration of IL-29 in GCF was increased to 85.99 pg/μl
in group 2 and to 114.64 pg/μl in group 3. Results of the present study
indicate that antiviral IL-29 level was highest in GCF of aggressive
periodontitis patients and least in subjects with healthy periodontium, while
that of chronic periodontitis lying in between. After non-surgical periodontal
therapy, IL-29 levels increased both in chronic and aggressive periodontitis
patients and deserve further investigation as a potential therapeutic agent in
treating periodontitis.
