Affiliations: Department of Biology, Laboratory of Genetics,
Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunis,
Tunisia | Department of Histopathology, Charles Nicolle
Hospital, Tunis, Tunisia | Department of Histopathology, The Oncology Institute
of Saleh Azaïez, Bab Saadoun, Tunis, Tunisia | The Institute of Genetics and Development of Rennes,
Rennes Cedex, France
Note: [] Corresponding author: Imen Ferchichi, Department of Biology,
Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of
Tunis, Tunis 1060, Tunisia. Tel.: +216 28 100 848; Fax: +216 71 231 401;
E-mail: [email protected]
Abstract: We investigate the expression and localization of the tumor
suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney
cancer. Both Aurora A kinase and pVHL protein status were evaluated using
immunohistochemistry. The Aurora A expression is correlated with the Fuhrman
grade and the TNM stage, while the pVHL expression is correlated with the
capsule rupture and the TNM stage. Aurora A kinase expression increases in
malignant tissue comparing to the non-malignant one. And there is a decrease in
pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two
kinds of opposite tumor profiles display significant distribution difference
according to TNM stages. It could be proposed that the absence of Aurora A
protein associated with a strong expression of pVHL in clear cells kidney
carcinoma are of good prognosis for the disease.
Keywords: pVHL, Aurora A, kidney cancer, immunohistochemistry
