Affiliations: Graduate Institute of Medicine, College of Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan | Division of Rheumatology, Department of Internal
Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan | Department of Biomedical Science and Environmental
Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung,
Taiwan | Division of General Internal Medicine, Department of
Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung,
Taiwan | Center of Excellence for Environmental Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan
Note: [] Corresponding author: Dr. Jeng-Hsien Yen, Division of
Rheumatology, Department of Internal Medicine, Kaohsiung Medical University
Hospital, No. 100 Zih-You 1st Road, Kaohsiung City 807, Taiwan. Fax: +886 7
3118141; E-mail: [email protected]
Abstract: To investigate the role of IκBα promoter polymorphisms in
the development of Behçet's disease, eighty-six patients with Behçet's
disease and 120 healthy controls were enrolled in this study. The
IκBα -881A/G, -826C/T,
-550A/T, -519C/T, and -297C/T polymorphisms were measured by the method of
polymerase chain reaction/ restriction fragment length polymorphism. This study
demonstrated that the genotype frequencies of
IκBα -826C/T and -826T/T were
significantly higher in the patients with Behçet's disease than in the
controls. Both in the dominant and in the recessive models, the patients with
Behçet's disease have higher frequencies of the
IκBα -826T containing
genotype than the controls. The allele frequency of
IκBα -826T was significantly
increased in the patients with Behçet's disease. The frequencies of the
IκBα -881A -826T -550A
-519C -297C and IκBα
-881A -826T -550A -519T -297C haplotypes were significantly higher in the
patients with Behçet's disease than in the controls. In contrast, the
haplotype frequency of IκBα -881A -826C -550A -519C -297C in the patients with Behçet's
disease was significantly decreased. This study also revealed that the
Behçet's disease patients with
IκBα -826T/T have higher
prevalence of skin lesions than those without
IκBα -826T/T. In summary, the
IκBα -826T allele,
IκBα -881A -826T -550A -519C
-297C and IκBα -881A
-826T -550A -519T -297C haplotypes might be associated with susceptibility to
Behçet's disease. The IκBα -826T/T genotype was related to the development of skin lesions in
the patients with Behçet's disease.
