Affiliations: Department of Internal Medicine, Chungnam National
University School of Medicine, Daejeon, Korea | Department of Preventive Medicine, Chungnam National
University School of Medicine, Daejeon, Korea | Department of Internal Medicine, Eulji University
School of Medicine, Daejeon, Korea
Note: [] Corresponding author: Kang Seo Park, Department of Internal
Medicine, Eulji University School of Medicine, 1306 Doonsan-dong, Seo-gu,
Daejeon, 302-120 Korea. Tel.: +82 42 798 6240; Fax: +82 42 790 1275; E-mail:
[email protected]
Abstract: Background: The serum concentrations of ferritin and adiponectin are
associated with several metabolic disorders and have been used as predictors of
insulin resistance and metabolic syndrome. But there have been no reports
demonstrating a direct correlation between serum ferritin and adiponectin
levels. We performed this study to evaluate the association between serum
ferritin and adiponectin concentrations. Subjects and methods: We evaluated a total of 995 subjects from the
Korea Rural Genomic Cohort Study in a population-based cross-sectional study.
Extensive clinical and laboratory measurements, including adiponectin and
ferritin concentrations, were recorded. Results: Univariate analysis revealed that the serum adiponectin
level was correlated with age, sex, BMI, diastolic blood pressure,
triglyceride, HDL-cholesterol, fasting blood glucose, fasting insulin, HOMA-IR,
hs-CRP, and ferritin. Multivariate analysis demonstrated that the adiponectin
concentration was correlated with age, BMI, fasting glucose, hs-CRP, and
ferritin. The ferritin concentration was the most powerfully associated with
serum adiponectin. In non-diabetic subgroups, the adiponectin level was
correlated with BMI, triglyceride, HDL-cholesterol, fasting glucose, and
ferritin level in multivariate analysis. In diabetic subgroups, the adiponectin
level was correlated with BMI, triglyceride, hs-CRP, and ferritin level in
multivariate analysis. Conclusions: The serum adiponectin concentration was correlated with
conventional clinical variables, but the most powerfully associated factor was
the serum ferritin level.
