Apolipoprotein E genotypes in Mexican patients with Parkinson's disease

Article type: Research Article

Authors: Gallegos-Arreola, M.P. | Figuera, L.E. | Ortiz, G.G. | Jiménez-Gil, F.J. | Ramírez-Vega, J. | Ruíz-Sandoval, J.L. | Puebla-Pérez, A.M. | Troyo-Sanroman, R. | García-Ortiz, J.E. | Sanchez-Corona, J. | Zúñiga-González, G.M.

Affiliations: Medicina Molecular, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México | Genética, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México | Neurociencias, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México | Centro de Investigación Biomédica de Occidente, Servicio de Neurología, UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México | Consulta Externa de Neurología, HGR110, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México | Hospital Fray Antonio Alcalde, Guadalajara, Jalisco, México | Laboratorio de Inmunofarmacología, Centro Universitario de Ciencias Exactas e Ingenierias, Guadalajara, Jalisco, México | Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México

Note: [] Corresponding author: Martha Patricia Gallegos Arreola, Sierra Mojada No. 800, Col. Independecia, Guadalajara, Jalisco, C.P. 44340, México. E-mail: [email protected]; [email protected]

Abstract: Background: The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. Method: In this study the possible relationship between Apo E alleles and PD patients was analyzed in 105 patients with PD and 107 healthy controls from a Mexican population. Results: Allele analysis in PD vs. controls was: ε2 in 6% and 2.3%, respectively; ε3 in 73% and 88.3%; and ε4} in 21% and 9.4%. The ε3 allele showed a protective risk effect with an Odds ratio (OR) of 0.36 (95%CI 0.20–0.61) and p < 0.05; contrary results were observed for the ε4 allele, which showed an increased risk for PD, with an OR of 2.57(95% CI 1.42–4.79) and p < 0.05. Upon multivariate analysis showed PD risk was evident in patients who were carriers of the genotype ε3/ε4; age group (fifty or more years) and had exposure to pesticides and solvents (p < 0.05). Conclusions: The ε3/ε3}; ε3/ε4 genotypes of the Apo E, were positively associated with sporadic PD.

DOI: 10.3233/DMA-2009-0667

Journal: Disease Markers, vol. 27, no. 5, pp. 225-230, 2009